Description
Interleukin 32 isoform A belongs to cytokine family. This protein expression is increased after the activation of T-cells by mitogens or the activation of NK cells by IL-2. It has the ability to induce proinflammatory cytokines such as TNFalpha and IL8 in THP1 cells, and activates typical cytokine signaling pathways involving NFkB and p38. IL-32 can also support osteoclast differentiation but not osteoclast activation by regulating the MAPK/ERK pathway and the actin cytoskeleton. Recombinant human Interleukin 32, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography